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TAKING TRYNGOLZA
TRYNGOLZA is an injection you give yourself
once a month with a convenient autoinjector
TRYNGOLZA comes in a single-dose autoinjector with either the 50 mg or 80 mg dose. Your doctor will determine the dose that's right for you. You will use a new autoinjector each time you take TRYNGOLZA.
80 mg
50 mg
Hover to inspect the parts of the autoinjector Inspect the parts of the autoinjector
Clear cap
Orange needle shield
Viewing window
Plunger
TRYNGOLZA should be injected into 1 of the following areas:
Abdomen (stomach)
Appropriate for self-injection
Front of the thigh
Appropriate for self-injection
Back of the upper arm
For healthcare providers or caregivers only to administer the injection
Download TRYNGOLZA Injection Quick Reference Guide (opens in new tab)
Helpful reminders about the proper way to use the TRYNGOLZA autoinjector
Tips for taking TRYNGOLZA
In addition to following the steps outlined in the Instructions for Use, these tips can help make taking TRYNGOLZA part of your routine.
Set a calendar reminder for the same day each month
So you never miss a dose
Take your TRYNGOLZA out to warm to room temperature
You can do this while you’re getting ready in the morning. That way, it’s ready to go when you are.
Choose a comfortable location to be when you take your injection each month
A comfortable chair, a nearby table for your supplies, and good lighting. Use a device to watch the TRYNGOLZA injection video, or have the TRYNGOLZA injection card handy.
Actor
portrayals.
With proper storage, TRYNGOLZA can go where you go
Store the autoinjector in the refrigerator between 36 °F and 46 °F (2-8 ºC) in the original carton.
If refrigeration isn’t possible, such as during travel, the autoinjector may be stored at room temperature between 59 °F and 86 °F (15-30 °C) in the original carton for up to 6 weeks.
Additional instructions and information on storing and injecting TRYNGOLZA can be found in the Instructions for Use inside the TRYNGOLZA packaging
Important safety information
Do not use TRYNGOLZA if you have had a serious allergic reaction to TRYNGOLZA or any of the ingredients in TRYNGOLZA.
Before using TRYNGOLZA, tell your healthcare provider about all of your medical conditions, including if you: are pregnant or plan to become pregnant, or are breastfeeding or plan to breastfeed. It is not known if TRYNGOLZA can harm your unborn baby, or if it passes into your breast milk and if it can harm your baby.
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
What are the possible side effects of TRYNGOLZA?
TRYNGOLZA can cause side effects including allergic reactions that may be serious. Allergic reactions can include redness of the skin, red itchy bumps (hives), swelling of the face, chills or trouble breathing. Stop taking TRYNGOLZA and call your healthcare provider or get emergency help right away if you have any of these symptoms.
TRYNGOLZA can cause increases in liver enzymes and fat stored inside the liver. Your healthcare provider may do liver tests before you start taking TRYNGOLZA or if there is an increase in your dose. Tell your healthcare provider right away if you have the following symptoms: feeling tired or weak, right upper stomach discomfort, yellowing of the skin and eyes, loss of appetite, or dark colored urine.
The most common side effects of TRYNGOLZA in people with FCS include injection site reactions (such as redness, itching, rash, or pain at the injection site), decreased platelet count (blood cells that help to clot blood), and joint pain or stiffness.
The most common side effects of TRYNGOLZA in people with sHTG include injection site reactions (such as redness, itching, rash, or pain at the injection site) and increased liver enzymes.
These are not all the possible side effects of TRYNGOLZA. Tell your healthcare provider or treatment team about any side effect you may have.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/safety/medwatch, or call
1-800-FDA-1088.
INDICATIONS
TRYNGOLZA (olezarsen) is a prescription medicine used along with diet to:
- Reduce triglycerides (fat in the blood) in the treatment of adults with a condition that keeps the body from breaking down fats called familial chylomicronemia syndrome (FCS).
- Reduce triglycerides and reduce the risk of acute inflammation of your pancreas (pancreatitis) in the treatment of adults with a condition marked by very high levels of triglycerides in the blood called severe hypertriglyceridemia (sHTG).
It is not known if TRYNGOLZA is safe and effective in children.
Please see full Prescribing Information and Patient Information for TRYNGOLZA.
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