TRYNGOLZA was proven 

safe and effective FOR lowering triglycerides 

in adults whose levels are very high


TRYNGOLZA was studied in 2 clinical trials. The primary goal of both trials was to
UNDERSTAND how well TRYNGOLZA 50 mg and 80 mg lowered triglycerides

In Clinical Trial 1, participants who took TRYNGOLZA 80 mg had a

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decrease in triglycerides

at 6 months compared with those who took placebo


The average starting triglyceride level was 1168 mg/dL.

Very high triglycerides are levels that are 500 mg/dL or higher. Your doctor may refer to this as severe hypertriglyceridemia.

In Clinical Trial 1

Participants who took 

TRYNGOLZA 50 mg experienced a 

63% decrease 
in triglycerides at month 6 compared with placebo, from an average starting level of 1169 mg/dL.

In Clinical Trial 2

Participants who took
TRYNGOLZA 50 mg experienced a 

49% decrease 
in triglycerides at month 6 compared with placebo, from an average starting level of 968 mg/dL.

Participants who took 

TRYNGOLZA 80 mg experienced a 
55% decrease
in triglycerides at month 6 compared with placebo, from an average starting level of 1088 mg/dL.

A secondary goal of Clinical Trials 1 and 2 was to 

MEASURE the number of sudden pancreatitis attacks

In both clinical trials, all participants who took TRYNGOLZA 50 mg or 80 mg were on average

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less likely to have a pancreatitis attack

at 12 months compared with those who took placebo

 

A sudden pancreatitis attack may also be referred to as acute pancreatitis. Pancreatitis is a painful, sometimes life-threatening, condition in which the pancreas becomes inflamed. Pancreatitis can cause intense stomach pain and organ failure. It may require a hospital stay for treatment.

Researchers studied how

TRYNGOLZA LOWERED TRIGLYCERIDES in 2 clinical trials:

Took place over 1 year

Included 1061 adult participants  
(18 years and older)

Every participant:

Had very high triglycerides (500 mg/dL or higher)

Followed a low-fat diet and lifestyle plan for at least 2 weeks prior to starting the trial and continued throughout

Had been taking standard triglyceride-lowering medications prior to and during the trial

Was assigned randomly to receive either TRYNGOLZA 50 mg  (354 adults), TRYNGOLZA 80 mg (351 adults), or placebo (356 adults)

Participant demographic and baseline characteristics were generally similar
 

None of the participants or healthcare professionals involved in the clinical trials knew who was being treated with TRYNGOLZA or taking the placebo (an inactive substance that looks the same as, and is given the same as, the active drug being studied). This is why the study is called a placebo-controlled, randomized, double-blind trial.

TRYNGOLZA SIDE EFFECTS

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TRYNGOLZA can cause side effects including allergic reactions that may be serious. Allergic reactions can include redness of the skin, red itchy bumps (hives), swelling of the face, chills or trouble breathing. Stop taking TRYNGOLZA and call your healthcare provider or get emergency help right away if you have any of these symptoms.

TRYNGOLZA can cause increases in liver enzymes and fat stored inside the liver. Your healthcare provider may do liver tests before you start taking TRYNGOLZA or if there is an increase in your dose. Tell your healthcare provider right away if you have the following symptoms: feeling tired or weak, right upper stomach discomfort, yellowing of the skin and eyes, loss of appetite, or dark-colored urine.

The most common side effects of TRYNGOLZA in people with very high triglycerides include:

  • Injection-site reactions (such as redness, itching, rash, or pain at the injection site)
  • Increased liver enzymes

These are not all the possible side effects of TRYNGOLZA. Tell your healthcare provider if you have any side effect that bothers you or that does not go away while taking TRYNGOLZA.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. 

Helpful TRYNGOLZA Resources

Download Discussing TRYNGOLZA With Your Doctor

Don't know what to ask your doctor? Bring this to your next appointment to help guide your discussion about TRYNGOLZA.

Download TRYNGOLZA Fact Sheet

Get the basics on very high triglycerides, how they impact your health, and how TRYNGOLZA can help.