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FREQUENTLY ASKED QUESTIONS
about starting treatment
GETTING STARTED on TRYNGOLZA
I haven’t signed up for Ionis Every Step™ yet. How do I enroll?
You can choose 1 of the following ways to enroll in the Ionis Every Step program:
- Visit TRYNGOLZA.com/Enroll and complete the Patient Authorization
- Call the Ionis Every Step Support Center at 1-844-789-8744 (select option 2) for more support or for help signing up
Will my insurance plan cover TRYNGOLZA?
Your doctor will work with your specialty pharmacy to see what information the insurance plan may need to approve TRYNGOLZA.
To help with this process, make sure your doctor has your up-to-date insurance information and knows how you are responding to your current treatment. Your doctor will send this information with your prescription directly to the pharmacy.
What if I don’t have insurance or my insurance plan doesn’t cover TRYNGOLZA?
If your insurance doesn't cover TRYNGOLZA or if you don't have insurance, you may be able to get your medication at no cost with the Ionis Every Step Patient Assistance Program*
*Subject to program terms, conditions, and limits. Ionis Every Step consent is required for participation in all Ionis Every Step coverage and affordability programs.
What can I do if my insurance plan denies coverage for TRYNGOLZA?
Medication denials are frustrating, but they can often be reversed. Your doctor can work with the pharmacy to ask your insurance plan to change their decision. This includes reading the denial letter and collecting materials to submit for review (also known as the appeal process).
To help with this process, you can check with your doctor to make sure they have all the information they need for the appeal. Ionis Every Step can also provide resources if you prefer to help with the process yourself and submit materials directly to the insurance plan.*
*Insurance approval is not guaranteed.
I’m switching insurance plans. Will my new insurance plan cover TRYNGOLZA?
Your doctor will work with your specialty pharmacy to check if TRYNGOLZA is covered under your new insurance plan. Reach out to your doctor once you have your new insurance information. If your new insurance plan doesn’t cover TRYNGOLZA, you still have options.
Ionis Every Step and our pharmacy partners will check if you qualify for support programs that may help with your out-of-pocket costs and access to TRYNGOLZA.*
*Terms and conditions apply. Programs subject to change or discontinue without notice, including in specific states. Ionis Every Step consent is required for participation in all Ionis Every Step coverage and affordability programs.
How do I get TRYNGOLZA?
Your specialty pharmacy will call to set up delivery of TRYNGOLZA right to your door.
It is important to save your pharmacy’s phone number so you recognize their call. TRYNGOLZA will not be shipped until you speak with the pharmacy about potential costs and setting up delivery.
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Click here for a list of pharmacy phone numbers
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If you're not sure which pharmacy you are using, or if you need additional support, call the Ionis Every Step Support Center at 1-844-789-8744 (select option 2), Monday to Friday, 8 AM to 8 PM ET
TAKING TRYNGOLZA
What if my medication is lost or damaged?
If your medication was not delivered when you were expecting it or if it arrives damaged, please reach out to your specialty pharmacy.
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Click here for a list of pharmacy phone numbers
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For more support, call the Ionis Every Step Support Center at 1-844-789-8744 (select option 2), Monday to Friday, 8 AM to 8 PM ET
I’m already on TRYNGOLZA and need a refill. Is there anything I need to do?
Reach out to your specialty pharmacy to let them know you need a refill and to make sure they have all the information they need.
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Click here for a list of pharmacy phone numbers
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For more support, call the Ionis Every Step Support Center at 1-844-789-8744 (select option 2), Monday to Friday, 8 AM to 8 PM ET
I’m going on vacation and need to get a refill early. What do I do?
Reach out to your specialty pharmacy to set up your next delivery and to make sure they have all the information they need.
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Click here for a list of pharmacy phone numbers
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For more support, call the Ionis Every Step Support Center at 1-844-789-8744 (select option 2), Monday to Friday, 8 AM to 8 PM ET
Important safety information
Do not use TRYNGOLZA if you have had a serious allergic reaction to TRYNGOLZA or any of the ingredients in TRYNGOLZA.
Before using TRYNGOLZA, tell your healthcare provider about all of your medical conditions, including if you: are pregnant or plan to become pregnant, or are breastfeeding or plan to breastfeed. It is not known if TRYNGOLZA can harm your unborn baby, or if it passes into your breast milk and if it can harm your baby.
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
What are the possible side effects of TRYNGOLZA?
TRYNGOLZA can cause side effects including allergic reactions that may be serious. Allergic reactions can include redness of the skin, red itchy bumps (hives), swelling of the face, chills or trouble breathing. Stop taking TRYNGOLZA and call your healthcare provider or get emergency help right away if you have any of these symptoms.
TRYNGOLZA can cause increases in liver enzymes and fat stored inside the liver. Your healthcare provider may do liver tests before you start taking TRYNGOLZA or if there is an increase in your dose. Tell your healthcare provider right away if you have the following symptoms: feeling tired or weak, right upper stomach discomfort, yellowing of the skin and eyes, loss of appetite, or dark colored urine.
The most common side effects of TRYNGOLZA in people with FCS include injection site reactions (such as redness, itching, rash, or pain at the injection site), decreased platelet count (blood cells that help to clot blood), and joint pain or stiffness.
The most common side effects of TRYNGOLZA in people with sHTG include injection site reactions (such as redness, itching, rash, or pain at the injection site) and increased liver enzymes.
These are not all the possible side effects of TRYNGOLZA. Tell your healthcare provider or treatment team about any side effect you may have.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/safety/medwatch, or call
1-800-FDA-1088.
INDICATIONS
TRYNGOLZA (olezarsen) is a prescription medicine used along with diet to:
- Reduce triglycerides (fat in the blood) in the treatment of adults with a condition that keeps the body from breaking down fats called familial chylomicronemia syndrome (FCS).
- Reduce triglycerides and reduce the risk of acute inflammation of your pancreas (pancreatitis) in the treatment of adults with a condition marked by very high levels of triglycerides in the blood called severe hypertriglyceridemia (sHTG).
It is not known if TRYNGOLZA is safe and effective in children.
Please see full Prescribing Information and Patient Information for TRYNGOLZA.