Support for Every Step™ | TRYNGOLZA® (olezarsen) Injection

TRYNGOLZA Carton

Assistance in accessing TRYNGOLZA

Ionis Every Step™ is a support program designed to help you manage the TRYNGOLZA treatment journey and connect you with resources along the way.

Programs that may help with your out-of-pocket costs for TRYNGOLZA

Ionis Every Step can work with our pharmacy partners to connect you with programs that may help with out-of-pocket costs for TRYNGOLZA, regardless of your insurance type.*

Support to help you get started and stay on track with TRYNGOLZA

Ionis Every Step stays connected with your pharmacy to provide you with support throughout treatment, including injection training, regular check-ins, and other assistance if you need more help using TRYNGOLZA.

*Terms and conditions apply. Programs subject to change or discontinue without notice, including in specific states. Ionis Every Step consent is required for participation in all Ionis Every Step affordability programs.

Getting started with Ionis Every Step for TRYNGOLZA

To access our support services, enroll in Ionis Every Step through one of the following ways:

1

Call Ionis Every Step at
1-844-789-8744
and ask to enroll

2

Complete the Patient Consent Form online

3

Fill out the TRYNGOLZA Patient Enrollment and Prescription Form in your doctor's office

Have questions about access and coverage?
Call Ionis Every Step at 1-844-789-8744
Monday to Friday, 8 AM to 8 PM ET.

To report any issues with your autoinjector, call Ionis at 1-833-644-6647.

Let's connect
Sign up to receive updates about TRYNGOLZA.

Important safety information & Indications

Important safety information

Do not use TRYNGOLZA^® (olezarsen) if you have had a serious allergic reaction to TRYNGOLZA or any of the ingredients in TRYNGOLZA.

Before using TRYNGOLZA, tell your healthcare provider about all of your medical conditions, including if you: are pregnant or plan to become pregnant, or are breastfeeding or plan to breastfeed. It is not known if TRYNGOLZA can harm your unborn baby, or if it passes into your breast milk and if it can harm your baby.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

What are the possible side effects of TRYNGOLZA?
TRYNGOLZA can cause side effects including allergic reactions that may be serious. Allergic reactions can include redness of the skin, red itchy bumps (hives), swelling of the face, chills or trouble breathing. Stop taking TRYNGOLZA and call your healthcare provider or get emergency help right away if you have any of these symptoms.

TRYNGOLZA can cause increases in liver enzymes and fat stored inside the liver. Your healthcare provider may do liver tests before you start taking TRYNGOLZA or if there is an increase in your dose. Tell your healthcare provider right away if you have the following symptoms: feeling tired or weak, right upper stomach discomfort, yellowing of the skin and eyes, loss of appetite, or dark colored urine.

The most common side effects of TRYNGOLZA in people with FCS include injection site reactions (such as redness, itching, rash, or pain at the injection site), decreased platelet count (blood cells that help to clot blood), and joint pain or stiffness.

The most common side effects of TRYNGOLZA in people with sHTG include injection site reactions (such as redness, itching, rash, or pain at the injection site) and increased liver enzymes.

These are not all the possible side effects of TRYNGOLZA. Tell your healthcare provider or treatment team about any side effect you may have.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/safety/medwatch, or call 1-800-FDA-1088.

Indications

TRYNGOLZA is a prescription medicine used along with diet to:

Reduce triglycerides (fat in the blood) in the treatment of adults with a condition that keeps the body from breaking down fats called familial chylomicronemia syndrome (FCS).
Reduce triglycerides and reduce the risk of acute inflammation of your pancreas (pancreatitis) in the treatment of adults with a condition marked by very high levels of triglycerides in the blood called severe hypertriglyceridemia (sHTG).

It is not known if TRYNGOLZA is safe and effective in children.

Please see full Prescribing Information and Patient Information for TRYNGOLZA.

Important safety information

Do not use TRYNGOLZA^® (olezarsen) if you have had a serious allergic reaction to TRYNGOLZA or any of the ingredients in TRYNGOLZA.

Before using TRYNGOLZA, tell your healthcare provider about all of your medical conditions, including if you: are pregnant or plan to become pregnant, or are breastfeeding or plan to breastfeed. It is not known if TRYNGOLZA can harm your unborn baby, or if it passes into your breast milk and if it can harm your baby.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

What are the possible side effects of TRYNGOLZA?
TRYNGOLZA can cause side effects including allergic reactions that may be serious. Allergic reactions can include redness of the skin, red itchy bumps (hives), swelling of the face, chills or trouble breathing. Stop taking TRYNGOLZA and call your healthcare provider or get emergency help right away if you have any of these symptoms.

TRYNGOLZA can cause increases in liver enzymes and fat stored inside the liver. Your healthcare provider may do liver tests before you start taking TRYNGOLZA or if there is an increase in your dose. Tell your healthcare provider right away if you have the following symptoms: feeling tired or weak, right upper stomach discomfort, yellowing of the skin and eyes, loss of appetite, or dark colored urine.

The most common side effects of TRYNGOLZA in people with FCS include injection site reactions (such as redness, itching, rash, or pain at the injection site), decreased platelet count (blood cells that help to clot blood), and joint pain or stiffness.

The most common side effects of TRYNGOLZA in people with sHTG include injection site reactions (such as redness, itching, rash, or pain at the injection site) and increased liver enzymes.

These are not all the possible side effects of TRYNGOLZA. Tell your healthcare provider or treatment team about any side effect you may have.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/safety/medwatch, or call 1-800-FDA-1088.

Indications

TRYNGOLZA is a prescription medicine used along with diet to:

Reduce triglycerides (fat in the blood) in the treatment of adults with a condition that keeps the body from breaking down fats called familial chylomicronemia syndrome (FCS).
Reduce triglycerides and reduce the risk of acute inflammation of your pancreas (pancreatitis) in the treatment of adults with a condition marked by very high levels of triglycerides in the blood called severe hypertriglyceridemia (sHTG).

It is not known if TRYNGOLZA is safe and effective in children.

Please see full Prescribing Information and Patient Information for TRYNGOLZA.